How we developed this life-saving technology

“Integrated” hydrocolloids were invented by a predecessor company of Xennovate Medical with the first patent for a hydrocolloid that did not “disintegrate” (hence the name, “Integrated”) due to moisture content over time. Hydrocolloids found their first large market in ostomy adhesives holding the collection bags securely onto the stomach without skin damage.

Nurses caring for and training ostomy patients at the time, then started noticing that the number and seriousness of skin problems typically seen around the stoma not only were failing to appear as they had in the past, but those with damaged skin from the use of Karaya Gum demonstrated full healing after starting to use hydrocolloids as their pouch adhesive.

Those peri-stoma skin healing successes led to a new use for hydrocolloids as moist wound healing bandages. The “pre-integrated” years held the risk of “…deep seated, unresolved inflammation in tissue that otherwise appears healed,” due to the melting of the hydrocolloid into the wound beds, while the integrated versions took that risk away per D. Chakravarthy, “Evaluation of three new hydrocolloid dressings: Retention of dressing integrity and biodegradability of absorbent components attenuate inflammation” J Biomedical Materials Res, Vol.28, 1165-1173 (1994).

Xennovate Medical currently offers four standard hydrocolloids in roll stock form to be sold to “converters” to create specialty hydrocolloid bandages for safer and more rapid healing and skin-friendly ostomy pouch adhesives. While Xennovate Medical stands ready to also create specialty formulae for your special needs, its standard roll stock formulae are:

xm18w | xm18o | xm18s | xm18e with the distinctive properties shown below. Each of these formulae were developed from the original formulation, which had superior properties, however, the cost of attaining those properties was a hurdle that needed to be overcome for more economical solutions.


xm18w | Designed specifically for Wounds — Exuding to heavily exuding wound bandages


xm18o | Designed specifically for Ostomy adhesive applications such as pouch rings, barrier rings, as well as barrier strips and arcs


xm18s | Designed specifically for high Shear needs for skin attachments such as Holter Monitors attached to the external chest wall.


xm18e | Designed specifically for Economical skin attachments that do not require the high absorption of the above formulae.

The “Performance vs Formula” graph below reflects the distinctive features built into each special Xennovate formula…

          As can be seen by the line graph of Saline Absorption, the highest level of absorption exists where it should be, that is, in the wound formula xm18w. The number of days of wear time will be driven by the degree of exudation exhibited by the wound on which it is applied. In general longer wear times are better, which take fullest advantage of the “moist wound healing” methodology, which in turn advocates faster healing due to as little opening of the wound to the environment as possible, especially in the wound’s earliest stages. Depending on the degree of exudate, xm18w might be worn without intervention from one day to as many as five days specified in the protocols at some wound healing specialty centers.


          Xm18o is designed specifically for use as an ostomy adhesive holding pouches to the skin or the skin-side of a 2-piece ostomy system while surrounding the stoma. The absorptive capacity need not be as great for ostomy as for wounds, because it is intended primarily to absorb skin moisture release (sweat) over time. Again, the number days depends in large part on the effective seal around the stoma and the individual’s quantity of normal perspiration (and the environment in which the individual lives). It is not unreasonable to expect the skin side of the 2-piece system to last in the range of 5-7 days.


          Xennovate’s xm18e formula was specifically designed for use in conjunction with skin attachment devices, as can be seen by the data showing notably less absorption with slightly higher sheer adhesion to the skin. The “e” stands for economical, as it has far less absorbers designed into it, which are key cost drivers. One sensible application would be for use in 1-piece ostomy pouching systems, which by design have way less wear time.


          The last of the four formulae highlighted here, xm18s, where the “s” stands for SHEAR adhesion, was specifically designed with that function in mind. It was designed in response to a project whereby the client sought a skin-friendly adhesive to hold a dimensional monitoring device to the chest wall. As the Z-dimension of a 3-dimensional device increases, the need for high sheer adhesion increases significantly. This formula worked. We later recommended it for use with a catheter stabilization device used on infants, and it has been sold for use in that application since 2010.

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